Scientific Talks

Sean Hill

Professor, University of Toronto Director, Krembil Centre for Neuroinformatics


10:20am EDT / 4.20pm CEST

Presentation: A multiscale approach to brain disorders

Abstract: Virtually all brain disorders involve alterations in neural excitability, brain connectivity, sleep, cognition, metabolism, and immune activity. Are these mechanisms and processes related to neuropsychiatric symptoms? Establishing a multiscale understanding of the causal relationships between the mechanisms underlying brain disorders and neuropsychiatric symptoms is particularly critical for mental health, where the lack of clear diagnostic criteria and precise treatment for highly heterogeneous conditions remains a grand challenge. In this presentation, using multiscale data-driven computational modeling, I explore the link between hyperexcitability, brain connectivity, sleep, and cognition, as well as implications for metabolism and immune activity. I then discuss the potential for testing this hypothesis and developing data-driven diagnoses and treatments.

Biography: Dr. Sean Hill is the Director of the Krembil Centre for Neuroinformatics, Senior Scientist at the Centre for Addiction and Mental Health (CAMH), and Professor at the University of Toronto. Dr. Hill is a computational neuroscientist with experience in building large-scale computational models of brain circuitry. The Centre collaborates with clinicians and researchers, employing neuroinformatics, artificial intelligence, and multiscale modeling, to develop data-driven definitions of brain disorders, predict patient trajectories, and transform mental health care. Dr. Hill applies large-scale data integration, neuroinformatics, multiscale brain modeling and machine learning to improve our understanding and treatment of mental health disorders. The Centre’s mandate is to accelerate global collaborations in brain science using the power of big data and brain modelling to fundamentally change how mental illness is understood.

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